Live Blogger: Paola Medina-Cabrera
Editors: Camila Gonzalez Curbelo, Ryan Schildcrout
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
What if doctors could fix a genetic disease the same way we fix a typo? All cells in our bodies contain DNA–an instruction manual that tells our cells how to function. But that manual contains mistakes. For decades, scientists could read these instructions but struggled to change them effectively. This changed with the discovery of CRISPR, a revolutionary gene-editing technology that allows researchers to identify and edit specific DNA sequences. At the 10th Annual 2026 RNA Symposium at the University of Michigan, Dr. Erik Sontheimer, a biomedical researcher at the University of Massachusetts Chan Medical School, discusses an exciting new step forward in this field: a technique called Prime Assembly, which allows scientists to insert large pieces of DNA into the genome more efficiently.
Continue reading “Dr. Erik Sontheimer: Prime Assembly with Linear DNA Donors Enables Large Genomic Insertions”
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