Author: Ada Hagan
Editors: Alisha John, Scott Barolo
As we discussed last time, bacteria that infect the human body face a major challenge: iron, which is essential for bacterial growth, is hard to obtain from human tissues. Many pathogenic bacteria solve this problem by deploying “stealth siderophores,” which steal iron from human iron-binding proteins while evading our defenses. In the battle between humans and pathogenic bacteria, our best weapons, antibiotics, are being weakened by widespread resistance. Is there a way to use bacteria’s need for iron against them?