From Bacteria to Bedside: FDA Approves First CRISPR-based Gene Therapy

Written by: Madison Fitzgerald

Edited by: Ryan Schildcrout, Jennifer Baker, Christina Del Greco, Ari Hoffman, and Emma Milligan

Illustrated by: Zoe Yeoh

We inherit a lot of things from our parents–an old jean jacket, family recipes, or even a penchant for dessert. On the cellular level, we inherit a set of genes from each of our parents that determine traits like eye color and blood type. In some unfortunate cases, people can inherit genes that cause disease. Most treatments that are currently available for genetic diseases help manage symptoms but are not curative because the disease-causing gene remains broken.

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La Genética y la Ilusión de Precisión

Autor: Christa Ventresca

Editores: Christina Del Greco, Andres Rivera Ruiz, Kate Giffin, and Jennifer Baker

Ilustración: Saaj Chattopadhyay

Traducción: Llilian Arzola Martínez y Rocío Cisneros 

Esta es la primera parte de una serie conformada por tres blogs que exploran el impacto de los análisis genéticos en la identidad personal. ¡Pronto publicarémos la segunda y tercera parte!

Si tienes curiosidad por descubrir la información que se oculta dentro de tu ADN, hoy en día disponemos de la tecnología necesaria para explorar nuestros genes. Puede ser que desees verificar el historial familiar de tus ancestros, o tal vez te preocupe la presencia de enfermedades genéticas en tu familia. Para obtener más información al respecto, puedes enviar una muestra de saliva a la empresa popular de análisis genéticos “23andMe”. Los resultados que recibirás incluirán una serie de estadísticas y números, todos ellos fundamentados en tu ADN. Sin embargo, ¿cómo interpretarás estos resultados? Y, ¿cuánta confianza tendrás en que todos los datos sean precisos?

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Decoding Herculaneum Scrolls with Artificial Intelligence

Written by: Julia Donovan

Edited by: Madison Fitzgerald, Kapil Shrawankar, Nick Janne, Ryan Schildcrout

When Mount Vesuvius erupted, it simultaneously destroyed the entire civilization of Pompeii whilst preserving the city under volcanic ash. Among the items excavated in 1752 was a collection of 1,800 scrolls from the nearby city of Herculaneum. The Herculaneum Scrolls are the only known large-scale library in classic antiquity. Given the small number of classical works that have survived beyond the period–Sophocles wrote 120 plays but only 7 remain–there is hope that these scrolls contain unknown works. Some researchers argue that only the best works from antiquity had a chance at survival, meaning the 7 plays of Sophocles that exist were his most popular ones. Evidence for this theory includes the fact that the Iliad was the most copied poem during antiquity, with many private manuscripts of the poem surviving to this day. Other experts argue that the survival of classical works is purely due to chance, supported by the fact that the poems by Catullus survive in only one manuscript. Similarly, the works of Sappho, which were highly regarded in her own times, exist only in fragments. Decoding the contents of these surviving scrolls could extensively add to the body of classical works. However, previous attempts to open the scrolls have led to their destruction. Due to the volcanizing of the scrolls, the brittleness of the papyrus causes breakage and the ink often fades when exposed to air. As a result, approximately 1,000 of the Herculaneum Scrolls remain intact. Researchers began to wonder if there was a way to see inside the scrolls without opening them, and if artificial intelligence (AI) could then help decode what was written. In 2023, AI aided in the discovery of the first word from a Herculaneum scroll. The path to this monumental step built on the AI research of many different labs.    

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