This piece was written in collaboration with the 2025 ComSciCon-MI Write-A-Thon.
Natural selection is happening all around us, shaping the living world and our future; we just need to observe. When Charles Darwin published The Origin of Species in 1859, he proposed a revolutionary idea: organisms within the natural world actually change over time, through a process he called adaptation by natural selection. What made his work so groundbreaking was not any specific discovery, but how he applied what he saw to explain how species adapt and diversify. Darwin demonstrated that by carefully observing the natural world, we can trace how small differences in individual beings accumulate into significant transformations over generations.
This piece was written in collaboration with the 2025 ComSciCon-MI Write-A-Thon.
Spinocerebellar ataxia type 3 (SCA3) is the most common inherited form of ataxia– a disordered loss of motor coordination. This rare, progressive disorder stems from a genetic error in the DNA sequence encoding the ATXN3 protein. Instead of functioning normally, this mutant protein becomes toxic, gradually damaging nerve cells.
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
“Doesn’t everyone want to increase their memory?” asks Dr. Shelley Berger.
Understanding the mechanisms that drive memory loss and aging is precisely the motivation for Berger’s ongoing and exciting research. Dr. Shelley Berger is a scientist in the epigenetics field – the type of science that studies how genes can be regulated without altering the DNA sequence. Authoring high-impact publications in Nature, Science, and Cell, Dr. Berger is undoubtedly a world-renowned expert who has advanced our understanding of many basic biological pathways and has worked to translate this knowledge into applications in medicine and beyond.
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
Dr. Nils Walter opens his keynote speech by acknowledging the 10th annual RNA symposium. As a co-founder of the Center for RNA Biomedicine here at the University of Michigan, his excitement for the innovations proposed here is palpable. We feel similarly here at Michigan Science Writers for our 10th year celebration. Walter goes on to say that RNA biomedicine is unique–it offers the fastest path from fundamental discovery to medicine. He emphasizes that this symposium is all about collaboration in working towards swift translation from discovery to medicine.
Editors: Camila Gonzalez Curbelo, Ryan Schildcrout
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
What if doctors could fix a genetic disease the same way we fix a typo? All cells in our bodies contain DNA–an instruction manual that tells our cells how to function. But that manual contains mistakes. For decades, scientists could read these instructions but struggled to change them effectively. This changed with the discovery of CRISPR, a revolutionary gene-editing technology that allows researchers to identify and edit specific DNA sequences. At the 10th Annual 2026 RNA Symposium at the University of Michigan, Dr. Erik Sontheimer, a biomedical researcher at the University of Massachusetts Chan Medical School, discusses an exciting new step forward in this field: a technique called Prime Assembly, which allows scientists to insert large pieces of DNA into the genome more efficiently.
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
The flow of genetic information is a fundamental concept in biology, and it’s one of the first major topics that most biologists learn in school. DNA is first transcribed into RNA and then RNA is translated into protein. However, the process is far more complicated than this simple framework suggests. Dr. Karla Neugebauer begins her talk by diving into the hidden complexities of this process. She asks us to recall that the average human gene contains 30,000 base pairs and each gene typically takes 30 minutes to transcribe. As RNA transcripts become longer, more RNA-binding proteins (RBPs) can bind and other activities (e.g., RNA editing, RNA splicing) can occur. This means there is roughly a 30-minute window of opportunity to influence nascent RNA, or the newly synthesized immature RNA transcripts, making them dynamic moving targets for regulation. This is an important step in translation, as RNA processing can have far-reaching biological consequences.
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
Huntington’s Disease (HD) is a fatal hereditary neurodegenerative disorder that typically emerges between the ages of 30 and 50. It’s a progressive disease that damages neurons in the brain that control voluntary body movement, resulting in uncontrolled dance-like movements called chorea and abnormal postures. Other symptoms of HD include changes in behavior, emotion, personality, and thinking. Despite modern medicine and all of our amazing medical advancements, there is still no cure for HD. This makes it especially important to understand the mechanisms underlying how HD damages these important neural cells.
This piece was written live during the 10th annual RNA Symposium, “RNA Frontiers: From Mechanisms to Medicine” hosted by the University of Michigan’s Center for RNA Biomedicine.
Michelle Hasting introduces the third Keynote Speaker at the RNA symposium by saying Madeleine Oudin has an incredible story to tell. While Dr. Oudin is well known for tumor resistance and tumor microenvironment research, her lab recently switched gears to an entirely new subject matter. Michelle concludes her introduction noting that she believes Oudin qualifies as one of the strongest scientists she knows in terms of the rigor she exercises within her research.
Written and Illustrated by Oanh Luc Edited by Alex Ford and Deanna Canizzaro
Some inspirations:
Title: B. F. Skinner (1935) in The Generic Nature of the Concepts of Stimulus and Response.
Thread (pg 2): Top: An ode to our laboratory friends. Left: Cardiac action potential. Middle: Graphs of platelet aggregation (e.g., Michael Holinstat lab in Pharmacology). Right: Ionic current trace. Bottom left: Cumulative records for fixed ratio and fixed interval schedules of reinforcement.
‘the most nonsensical of All…’ (pg 4): Albert Einstein wrote in 1936, “The very fact that the totality of our sense experiences is such that by means of thinking (operations with concepts, and the creation and use of definite functional relations between them, and the coordination of sense experiences to these concepts) it can be put in order, this fact is one which leaves us in awe, but which we shall never understand. One may say ‘the eternal mystery of the world is its comprehensibility.’”
Bottom left panel (pg 4): Dose-response curve
Oanh Luc is a graduate student in pharmacology. She is keeping on.
Written by Matthew Blacksmith Edited by Emily Januck and Alex Ford Illustrated by Danny Cruz
Imagine you are in a classroom, sitting at your desk, and it is the middle of winter. The teacher is giving a lesson and as you look around, you see red noses and tired eyes. As you listen, you hear sniffles and coughs. These sniffles and coughs represent a battle occurring on a scale too small to see. The cells of your body fight to keep you healthy, while viruses, bacteria, and other germs fight to use your cells to reproduce. Viruses exist on the spectrum between being alive and dead. Unlike living creatures, they are not able to reproduce on their own. Instead, they inject your cells with virus DNA and proteins. These viral components hijack the ordinary functions of your cells to turn them into a viral factory. Much like a double agent, these cells will copy virus genetic code, produce virus proteins, and assemble them together to generate new viral copies that are every bit as infectious as the original. From there, viruses can cause the cell to rupture, releasing the newly produced viral particles in a chain reaction to infect nearby cells.1
Off the top of your head, you can probably think of various diseases caused by viruses. The viruses that cause smallpox, chicken pox, and most recently, COVID-19 make humans sick as part of their viral “life” cycle. These and other viruses have been an enormous burden to society and human health across history. Smallpox alone was responsible for over 300 million deaths during the 20th century, and was considered such a public health emergency that the entire world banded together to eliminate smallpox entirely.2 Thanks to vaccine technologies developed to fight it, there have been no naturally occurring cases in nearly fifty years, making the smallpox virus the first and only human disease that has been eradicated from face of the planet.3,4
Human ingenuity may have utilized vaccines to eradicate smallpox, but there are many other diseases for which vaccines may not be effective that still require time, attention, and resources to combat effectively. One such example is the bacterium Mycobacterium tuberculosis, which is responsible for the disease tuberculosis.5 While it is frequently thought of as a disease of the past, over 10 million people contracted symptomatic tuberculosis in 2023. 6 Even more astoundingly, approximately one out of four people are infected with tuberculosis at some point in their life.6 While tuberculosis can be cured with antibiotics, the treatment is extensive and requires continuous medication for months or even years.7 Unfortunately, 450,000 people in 2021 were infected by strains of tuberculosis immune to the antibiotic rifampicin, a first-line anti-tuberculosis treatment.8 As more and more diseases grow resistant to antibiotics and other medicines, new treatment avenues must be explored.
Drug resistant tuberculosis is only one example of the growing wave of infectious diseases that are developing antimicrobial resistance. When they do, treatment becomes more difficult and the human cost of disease increases.9 Over a million deaths worldwide can be directly attributed to disease variants that are antimicrobially resistant. In addition to the loss of life, it is predicted that by 2050 between $330 billion and $1 trillion of additional healthcare costs will be incurred annually.10 The fighting of antimicrobial resistances is a priority worldwide, and many standard practices are being adopted, such as maintaining good hygiene, prescribing antimicrobials judiciously, and taking the full course of antibiotics.11 However, none of these factors matter when someone already has a disease caused by a pathogen with antimicrobial resistance. This conundrum has left scientists around the globe to ask: in this microscopic arms race, what new treatments can be developed to fight disease?
Enter: the bacteriophage. Unsurprisingly, not all viruses prefer human cells as targets. Some selectively infect animals, plants, fungi, and even bacteria. The scientific name for a virus that infects bacterial cells is a “bacteriophage.” Bacteriophages represent an important part of the microscopic world around us. Just as the varicella-zoster virus infects our cells to yield chicken pox, bacteriophages infect and kill bacteria such as tuberculosis. If it seems like a strange idea to weaponize viruses against disease causing bacteria, it may be worth remembering the saying: the enemy of my enemy is my friend.
Let’s put you in the shoes of a scientist looking for bacteriophages to treat tuberculosis. How would you start? One thing to remember is that most bacteriophages only infect a single species of bacterium, so not just any bacteriophage will do. A good first step is to take a Petri dish covered in a layer of bacteria food and cover it with purified Mycobacterium tuberculosis. This will create a bacterial “lawn”. You can then drop small amounts of bacteriophages onto the lawn until you find one or more that kill the bacteria on the plate. However, just because the bacteriophage works on cells in a dish doesn’t mean that they will work in the human body. In a 2024 study, two bacteriophages were found to kill Mycobacterium tuberculosis on bacterial lawns. When progressing to later experiments, one bacteriophage strain called DS6A showed continued promise in the testing of human immune cells. Even more interestingly, after exposure to Mycobacterium tuberculosis mice treated with bacteriophage DS6A showed more weight gain than those with no treatment, a sign that the treatment was at least partially successful.12 The DS6A bacteriophage makes an excellent candidate for further testing to improve human health.
While the FDA hasn’t yet fully approved any bacteriophage therapy, that isn’t to say that bacteriophages have never been used in humans. In 2015, Tom Patterson was enjoying a cruise while traveling with his wife, Dr. Steffanie Strathdee. While abroad, he became sick and ultimately developed a large abscess which was infected with a strain of antibiotic-resistant Acinetobacter baumannii. In a stroke of luck, his wife worked as an epidemiologist and used her expertise to acquire bacteriophages which might work against Tom’s condition. After receiving emergency special permission from the FDA, custom bacteriophage “cocktails” were prepared. Tom was on the verge of death when the bacteriophage cocktails were injected into his bloodstream and abscess. In a near miraculous turn of events, he awoke from his coma and has lived for years after being treated.13,14 Despite being only a single case, Tom’s amazing recovery serves as an example that bacteriophages can be used to treat infections, improve outcomes, and save lives.
Tom’s case is representative of a growing number of bacteriophage therapies that are personalized to the needs of a single patient. A review of one hundred patients who received personalized bacteriophage therapies found that over 75% of infections showed clinical improvement after bacteriophage treatment. Interestingly, bacteriophage treatments used in combination with antibiotics were more likely to be successful than bacteriophages alone, showing that bacteriophages can be used with existing treatments rather than solely as a replacement.15 However, before being ready for widespread use, bacteriophage therapies will have to pass through clinical trials. Clinical trials exist to prove that new treatments are safe and effective at treating a condition.16 Numerous trials are investigating if bacteriophages can treat ventilator associated pneumonia, diabetic foot osteomyelitis, urinary tract infections, acute tonsillitis, infections of prosthetics, and many other conditions. 17-18 In fact, over 40 clinical trials of bacteriophage treatments are currently underway in the United States and another 50 are ongoing around the world.19 Time will tell how many of these treatments will be successful enough for widespread use.
As with all medical treatment, bacteriophages have some limitations and potential side effects to consider as well. Bacteriophages do not infect human cells but our immune systems can still identify and attack them, potentially leading to inflammation.20 Furthermore, just as bacteria develop resistance to individual antibiotics, they can become resistant to one or more bacteriophages.15 And not all bacteria have known bacteriophages which can infect them.21 This means that at least for now, bacteriophage therapy has room to develop before it’s ready for the big leagues.
Keeping both the pros and the cons in mind, bacteriophages show great promise as an unlikely ally against bacterial diseases. In addition to being injected into the bloodstream, they may be used topically to treat skin infections and burn wounds, orally to treat gastrointestinal illnesses, or inhaled to treat respiratory diseases.22 In the arms race between humans and disease, bacteriophages represent a new weapon that may be available soon to continue the fight against bacterial infections. Medical treatments that haven’t been discovered or approved yet have the potential to keep kids healthy, combat antibiotic resistant diseases far into the future, pair with existing treatments to enhance their effectiveness, and ultimately save lives. What was a miraculous cure for Tom Patterson may one day be an everyday wonder in our medical arsenal against bacterial diseases.
Matthew Blacksmith is a PhD student in the Department of Human Genetics studying canine mobile elements in the labs of Drs. Jeffrey M. Kidd and John V. Moran. In his free time he enjoys board games, video games, and walking his dog at local parks.
References:
Virus Definition. Scitable by Nature Education, Nature website
Simonsen and Snowden. Smallpox. National Center for Biotechnology Information website (2023)
About Smallpox. Center for Disease Control website (2024)
Drug-Resistant Infections: A Thread to Our Economic Future. World Bank (2017)
Antibiotic Resistance. National Foundation for Infectious Diseases website (2024)
Yang et al. Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice. Communications biology (2024)
Lamotte. No antibiotics worked, so this woman turned to a natural enemy of bacteria to save her husband’s life. CNN website (2023)
Schooley et al. Development and Use of Personalized Bacteriophage Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Antimicrobial Agents and Chemotherapy (2017)
Pirnay et al. Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multicentre, multinational, retrospective observational study. Nature microbiology (20 24)
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