This piece was written LIVE during the 5th annual RNA Symposium: Processing RNA. Follow us on Twitter or the tag #umichrna!
Live blogger: Logan Walker
Editor: Alyse Krausz
Over the last two days, we have heard talks all about how RNA is a key building block in myriad biochemical processes, both natural and artificial. But, with all of this RNA floating around, we are left with a simple question: what happens to the RNA molecules once our cells are “done” with them? The answer turns out to be a constellation of proteins that work together to detect incorrect sequences, turnover old RNA molecules, perform post-translational modifications, and remove invasive sequences, such as viral RNA molecules. In the case of RNA turnover, much of this processing is performed by the RNA exosome complex, making it an important target of study for diseases where it is dysregulated, such as multiple myeloma, pulmonary fibrosis, and many subtypes of cancer.Continue reading “Dr. Christopher Lima: Control of RNA degradation in the exosome”