Trash Talk

Author: Sara Wong

Editors: Sarah Kearns, Ellyn Schinke, and Shweta Ramdas

Taking out the trash is a despised chore. It’s smelly and heavy, and you have to get off the comfortable couch, put on shoes, and take it all the way to the curb. Yet, we do it because we understand that it is important for the health of our homes and neighborhood, and taking out the trash is better than leaving it in the house.

What you might not realize is that your cells also have to take out the trash. In fact, defects in this process often lead to disease. One example is Niemann-Pick disease, which in severe cases causes death in early childhood. Neimann-Pick disease is caused by defective lysosomes, the trash bins of the cell. In order to understand diseases like Niemann-Pick disease, we must first understand lysosomes.

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The budding brain: How yeast give rise to treatments for neurodegenerative diseases

By Sara Wong

What do humans and baker’s yeast have in common? Surprisingly, they share a massive amount of genetic information and are governed by many of the same cellular processes. Although yeast do not have organs or limbs, they work like human cells and can be used to study a wide range of human diseases. Yeast are cheap, grow quickly, and are easily manipulated. These qualities allow scientists who study yeast to discover new genes and pathways relatively easily compared to other model organisms, like mice. One area of yeast research focuses on understanding neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease.

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