The assassins have a description of their targets, who are hiding in plain sight among the non-combatants. The targets are guerillas who’ve infiltrated the neighborhood, overwhelming the local authorities and fomenting chaos. After only minutes on patrol, the assassins go on the attack, quickly identifying and eliminating the enemy without harming a single bystander.
This scenario may sound like the plot of a Hollywood blockbuster, but it’s also a good metaphor to describe the activity of engineered immune cells against cancer cells. The assassins are called CAR-T (Chimeric Antigen Receptor-T) cells, and they receive their elite training at the hands of physicians and scientists, who teach them to recognize particular molecules on the surface of tumors.
Editors: Brittany Dixon, Zuleirys Santana Rodriguez, Scott Barolo
Zebrafish may not look impressive, but they can do something that no human can: regenerate large portions of organs that are damaged or lost. These fish, each about as long as your pinky finger, are able to regrow amputated fins, repair lesioned brains, and mend damaged eyes, spinal cords, and hearts. This remarkable ability to heal has fascinated scientists for some time, and in recent years, large strides have been made towards translating this regenerative ability to humans. Continue reading “Regenerative medicine – Panacea or hype?”
It turns out that what your ancestors ate can influence your ideal diet. At least, that’s what researchers at Cornell University and the University of Pune, in India, have announced after analyzing several hundred peoples’ genomes and blood samples in the United States and India.
We live in an age where oversharing is overabundant. From your best friend’s artsy food pictures (#boozybrunch), to your coworker live-Tweeting her labor experience (“C-section in 20 minutes!”), it seems like we know the intimate details of everyone’s lives, all the time.
But what if some of those TMI moments weren’t necessarily “too much information”? What if they’re actually helping to solve one of the biggest dilemmas in human genetics: the identification of disease-causing genes?
In 1917, almost a century ago, a French-Canadian scientist, Felix d’Herelle, and his colleagues discovered bacteriophage. As I discussed in a previous post, bacteriophage (phage) are the viruses that prey on bacteria, turning them into viral factories. The battle between phage and bacteria has raged for millennia, resulting in a beautiful co-evolution where predator and prey each grapple for a temporary upper hand.
We’ve been exploring the depths of this complex relationship, searching for ways to use this enemy of our enemy as a tool against the bacterial infections that plague us. Along the way, we’ve found a number of different techniques to exploit these micro-allies.
Growing up, I was an avid soccer player. But, I never wanted the glory of being a team’s leading scorer. Defense was my home. That is until I scored my first goal. I was elated, but quickly realized that I had never in my time on defense received anywhere near the validation that I had for that goal. I could save goals or shut down the other team’s star player, but that usually went unnoticed. If anything, I was typically criticized for something I didn’t do more often than I was praised for something I did. This experience taught me something important – defense is a thankless job.
The same pattern that I saw in my soccer experience happens all the time with public health.
MiSciWriters is proud to partner with the UM Center for Microbial Systems to provide live coverage of the 2016 Michigan Meeting “Unseen Partners: Manipulating Microbial Communities that Support Life on Earth.” In lieu of our traditional Tuesday post, we will be live-blogging the event at the links below, and live-tweeting from @MiSciWriters during the following times:
Monday, May 16 9:00am-3:30pm, 7:00-8:30pm
Tuesday, May 17 9:00am-3:30pm, 7:00-8:30pm
Wednesday, May 18 9:00-12:00
We hope you’ll join in the conversation by commenting on the blog, or tweeting with the hashtag #MiMicrobe. Enjoy!
Update: Live blogging coverage is released as an event unfolds, placing the posts in reverse-chronological order. So if you want to read everything, start from the bottom of the page.