Versión original en inglés escrita por Noah Steinfeld, traducida al español por Thibaut R. Pardo-García y editado por Sofía A. López.
A principios de 1950 en la Universidad Johns Hopkins, William E. McElroy, profesor joven, quiso descubrir que hace que las luciérnagas resplandezcan. Él le pagaba veinticinco centavos a niños en el área de Baltimore por cada 100 luciérnagas que le trajeran. McElroy era visto como una curiosidad en la comunidad: el estereotipo de un científico excéntrico. Pero, lo que estas personas no sabían es que, como resultado de su investigación, un día McElroy crearía una herramienta que revolucionaría la forma en que los científicos ejercen las investigaciones biológicas.
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Author: Noah Steinfeld
Editors: Alex Taylor, Christina Vallianatos, and Bryan Moyers
In 2001 the Nobel Prize in Physiology or Medicine was awarded to three scientists, Leland Hartwell, Tim Hunt and Paul Nurse, for their discoveries of key regulators of the cell cycle. Normally, before a cell can divide, it must undergo several phases of the cell cycle in a precise order. First, a cell grows in size, then duplicates its DNA, and finally distributes its DNA evenly between two daughter cells. The three researchers played seminal roles in identifying the mechanisms by which cells transition from one cell cycle phase to the next.
These fundamental discoveries are not only crucial to our understanding of biology, but have applications in human disease. Many types of cancer are linked to mutations that cause cells to move quickly through or even skip some parts of the cell cycle, making cell cycle regulation a hot area of biological research. Given the implications this research has for human health, it might surprise you that many cell cycle regulators were not first discovered in humans. Instead, these cell cycle regulators were identified and characterized in model organisms including yeast and sea urchins.
“But what do I have in common with the yeast I use to bake bread?” you might ask. As it turns out, a lot more than you’d think.
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By Noah Steinfeld
In the early 1950s at Johns Hopkins University, William E. McElroy, a young professor, wanted to figure out what makes fireflies glow. He would pay a quarter to children in the Baltimore area for every 100 fireflies they brought him. McElroy was regarded as a curiosity in the community: the stereotype of an eccentric scientist. But what these people didn’t know was that as a result of this research, McElroy would one day create a tool that would revolutionize the way scientists do biological research.
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