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Live blogger: Alyse Krausz
Editor: Logan Walker
CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats) is well-known as “molecular scissors” that enables scientists to edit DNA. But there’s more to CRISPR technology than just cutting and pasting DNA! In bacteria, the many CRISPR-Cas systems provide a defense system against viral infections, and viruses use DNA or RNA as their genetic material. Nature has evolved some CRISPR-Cas systems that target DNA, such as CRISPR-Cas9, and others that target RNA, such as CRISPR-Cas13. Dr. Feng Zhang, a Professor of Brain and Cognitive Sciences and of Biological Engineering at MIT, and his lab have discovered and developed the CRISPR-Cas13a system for use as a diagnostic tool. Their lab has harnessed CRISPR-Cas13a as a biotechnology to create a molecular detection platform called SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) capable of detecting RNA or DNA with high sensitivity and specificity.
Continue reading “Dr. Feng Zhang: Harnessing Biological Diversity for COVID-19 Diagnostics”