Placebos: Tricking the Brain, Targeting the Body

Author: Shweta Ramdas
Editors: Charles Lu, Whit Froehlich, and Scott Barolo

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Placebo or Nocebo?

Last year, when I pooh-poohed my mother’s alternative medicine regimen, she said, “But these actually work well for me, because I believe in them!” My mother had just outsmarted me with science.

The placebo effect is one of the most remarkable yet least understood phenomena in science. It is a favorable response of our body to a medically neutral treatment (sugar pills, anybody?): in other words, a placebo is a fake treatment that produces a very real response. This is attributed to a physical reaction stemming from a psychological response to the administration of therapy. You could say that a patient sometimes gets better anyway—how many times have we waited out the common cold—and you would be right. This natural return to the baseline which can happen is not considered the placebo effect, which is an improvement in response to a treatment.

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