Tag: epigenetics

The influence of epigenetics in breast cancer therapeutics

Author: Jessica McAnulty
Editors: Tricia Garay, Stephanie Hamilton, and Whit Froehlich

Most likely, you know of someone diagnosed with breast cancer, which affects 1 in 8 women in the United States. Some of the reasons this disease is so difficult to treat are the lack of targeted therapies (as there are different subtypes of breast cancer) and tumor resistance to treatment. Therefore, scientists are investigating novel therapies that act on a specific component of the cancer and/or prevent this resistance. One exciting therapy alters the expression of certain genes; a gene needs to be expressed, or “turned on”, in order for the cell to obtain information from the gene and produce a product. This therapy is a promising approach since cancers, such as hormone-sensitive breast cancer, are often due to genetic mutations that result in an increase in gene expression. It is thought that using this therapy to alter gene expression will reverse the breast tumor’s resistance to treatment.

Methylated Memory

Author: Sarah Kearns

Editors: Naiyiri Kaissarian, Patricia Garay, and Shweta Ramdas

If you saw a hippo on campus, you would remember it. But, would you expect that seeing such a pachyderm roaming on a university would alter the expression of your DNA? A recent study found that rats placed in an environment that tested their memory had alterations to their DNA, or epigenetic changes.

For a long while, we have generally known that neurons within the hippocampus of our brains are responsible for memory. The current model for memory storage is due to the plasticity of neuronal connections, but researchers have recently found that it also involves active changes at the genetic level. These changes come from external factors and are linked to retaining long-term memories, which has implications in stress-related learning and memory disorders.

It’s all in the family! The biology of inheritance, part 1

Author: Shweta Ramdas

Editors: Molly Kozminsky, Jimmy Brancho, Kevin Boehnke

 

Harry Potter has his mother’s eyes. From his father, James, he inherits his black hair, his ability to play Quidditch, and a certain predisposition to mischief. We are all unique combinations of our parents, receiving half our DNA from each. In the genetic lottery, our parents’ genes are scrambled and spliced to create a new individual who carries on the family’s long tradition of snoring into one’s sheets. But besides a rickety knee, shortness of stature, and preferred pizza toppings, what else can we blame on our parents?

Mother’s protein intake can affect her child’s weight

Author: Shweta Ramdas

Editors: Ada Hagan, Alisha John, Bryan Moyers, and Irene Park

Google “diet for pregnant or nursing mothers”, and you’ll be swamped with web pages recommending foods that help the baby and foods to avoid. There has been considerable research indicating that the diet of pregnant mothers can affect the child’s health (including risk for schizophrenia). But how? And are these effects long-lasting, or do they wear off once the child hits adulthood?

X: A reason calico cats xist.

By Shirley Lee

 

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Samantha. Image credit: Shirley Lee

Last year, I decided to add a new member to my family, which at the time consisted of simply yours truly (well, other members of the family do exist but live hundreds of miles from Ann Arbor). After some searching, I brought an orange tabby cat back to my apartment and named her Samantha (pictured at the top). Samantha is a domestic shorthair, with faint mackerel markings along the sides of her body. Her forehead bears the classic “M” pattern characterizing a tabby cat. She also has four stripy legs, pink paw pads, and an orange stripy tail. When I introduced her to my family back home, she wasted no time in conquering everyone with that fuzzy face!